The Science of Barology


FERTILITY BARS

  • It is ideal to start the supplementation three months prior to fertility treatment; however, starting these supplements at any time may help to improve egg quality.
  • It is recommended to take a prenatal vitamin with DHA daily along with these supplements.
  • STOP the supplements(except for the prenatal vitamin with DHA) with the trigger shot (HCG) or with ovulation.

Female Fertility Blend

Co Enzyme Q10    |    200 mg TID

MECHANISM OF ACTION

Commonly used for heart disorders
Helps support and improve mitochondrial function
(which is the powerhouse of the cell)
Required for mitochondrial ATP synthesis (provides energy)

Vitamin E    |   200 IU QD

MECHANISM OF ACTION

May improve glandular epithelial growth and development of blood vessels in the endometrium.
Antioxidant
Helps prevent oxidative mitochondrial damage.

Omega-3 Fatty Acid   |    100 mg QD

MECHANISM OF ACTION

n one study, a higher omega-6 to omega-3 ratio was associated with higher numbers of follicles
Recommend increased omega-3 intake (leafy greens, nuts and seeds and high quality,purity tested fish oil supplement), and lower omega-6 fats intake (found in snack and fast foods, factory/grain-fed red meat and processed oils)

L-arginine   |   1000 mg BID

MECHANISM OF ACTION

Amino acid
Encourages your pituitary gland to produce more Human Growth Hormone, which helps improve the quality and quantity of eggs.t

Vitamin C   |   500 mg QD

MECHANISM OF ACTION

Antioxidant
Helps prevent oxidative mitochondrial damage.
Supports healthy blood vessel structure

Pycnogenol   |   100 mg QD

MECHANISM OF ACTION

Effective against fat soluble and water soluble free radicals.
Supports healthy blood vessel structure
Super antioxidant and has anti-inflammatory effects.

womens_eggs

Women’s Fertility Vitamins to Improve Egg Quality

Every woman is born with all the immature eggs that she will have in her lifetime period. The eggs lie dormant in the ovaries, waiting to become activated by hormones. Environmental factors that eggs are exposed to such as toxins, chemicals, and any nutritional deficiencies, can affect the quality of these eggs waiting to become activated.

Antioxidants are vitamins, minerals and other nutrients that help to protect the body from the damage caused by free radicals, which are unstable molecules that can damage cell structure. Research indicates that egg cells are highly susceptible to harm from free radicals, the unstable oxygen molecules that are produced as the body breaks down toxins.


BAROLOGY FERTILITY BLEND

CoQ10

Has potent antioxidant properties that help to stabilize cell membrane to enhance egg quality. It is produced by the body, however production declines with age. Low CoQ10 can result in decreased energy production and increased oxidative stress. It helps support and improve mitochondrial function, which is the powerhouse of the cell, providing a fertililzed egg energy to divide and implant. CoQ10 is required for mitochondrial ATP synthesis, or energy production.


Omega 3 Fatty Acids

Fatty acids that when supplemented can help produce a higher number of follicles. Omega 3’s comprise many chemicals that reduce inflammation and support the health of cell membranes. Recent research shows that there may be a link between consuming omega 3’s and delayed ovarian aging and improving egg quality.


Vitamin C

Is another important antioxidant. It helps to repair damage caused by the enformonment and aging. Vitamin C supports healthy blood vessel structure and reduces blood pressure and inflammation. Vitamin C may be involved in the release of progesterone and may be effective treatment for luteal phase defect. According to a study published in Fertility and Sterility, a moderate amount of supplemental vitamin C improves hormone levels and increases fertility.


Vitamin E

Vitamin E is an antioxidant that helps to prevent oxidatitive mitochondrial damage to the egg. It may also improve glandular epithelial growth and development of blood vessels in the endometrium. Vitamin E is incorporated into the lipid (fatty) part of the cell membrane, where it stabilizes and protects the cell membrane from toxic compounds including lead, mercury and other heavy metals,cleaning solvents (all known endocrine disruptors); medications; radiation; and free-radicals Some studies also suggest that Vitamin E can lengthen the luteal phase of the cycle.

Pycnogenol (pine bark extract)

Is a super potent antioxidant. It is effective against fat soluble and water soluble free radicals. Pycnogenol has anti-inflammatory effects and supports blood vessel structure. Antioxidants may help diminish the toxic effects of oxygen-free radicals that can accumulate in the follicular fluids surrounding eggs.

L-argninine

An amino acid that encourages the pituitary gland to produce more human growth hormone which in turn helps improve the quality and quantity of egg production. L-arginine allows for better blood circulation to the ovaries, which can allow for optimum egg production, creating a better environment to allow for the implantation of a fertilized egg.

- See more at: http://www.fertileaction.org/learning-center/parenthood-ater-cancer/supplements /#sthash.e3305njV.dpuf

• Hammiche F, Vujkovic M, Wijburg W, de Vries JH, Macklon NS, Laven JS, Steegers-Theunissen RP. Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertil Steril. 2011 Apr;95(5):1820-3.

• Kim JY, Kinoshita M, Ohnishi M, Fukui Y. Lipid and fatty acid analysis of fresh and frozen-thawed immature and in vitro matured bovine oocytes. Reproduction. 2001 Jul;122(1):131-8.

• Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder M. Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell. 2012 Dec;11(6): 1046-54.

Nehra, D., Le, H. D., Fallon, E. M., Carlson, S. J., Woods, D., White, Y. A. , ... & Puder, M. (2012). Prolonging the female reproductive lifespan and improving egg quality with dietary omega‐3 fatty acids. Aging cell, 11(6), 1046-1054.

Murray, Michael T., N.D. Encyclopedia of Nutritional Supplements The Essential Guide for Improving Your Health Naturally. Three Rivers Press, 1996

Male fertility blend

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Sperm cells require energy to function, because of this need, they generate oxidation—which can ultimately damage cell membranes, DNA molecules, and the very mitochondria that power the cell in the first place. There's a well-known association between oxidant stress, the antioxidant capacities of sperm cells and semen, and final sperm quality. In general, men with elevated markers of oxidation show impaired sperm count and more abnormally-formed cells.

Coenzyme Q10 is a vitamin-like substance found in body cells, especially in the heart, kidney, liver, and pancreas, that may promote health and fight some diseases. Scientists believe CoQ10 functions as an antioxidant that blocks actions that can damage cells. New studies have found that supplements of CoQ10 can help improve sperm movement in infertile men.

VITAMIN C is an important anti-oxidant that helps prevent sperm defects and boosts sperm motility. Studies have shown that lower levels of vitamin C may lead to infertility and increased damage to the sperm's genetic material.

VITAMIN E is a powerful antioxidant that improves sperm count, quality, and motility. It helps keep the sperm membrane healthy and protects sperm from free-radical damage. Studies show that vitamin E supplements improve the sperm’s overall ability to penetrate an egg. IVF success rates are higher for couples in which the man takes vitamin E supplements.

ZINC- Zinc deficiency is associated with poor sperm quality resulting from increased oxidant stress in seminal plasma, the liquid portion of semen that is responsible for maintaining sperm cells in a healthy state. Depletion of zinc also reduces the volume of semen produced. Studies in both animal models and humans demonstrate significant improvements in sperm quality following zinc supplementation, especially in cases of known infertility. Supplementation increases sperm counts, mobility, and fertilizing capacity, and decreases levels of DNA damage, structural abnormalities in sperm, and levels of antibodies to sperm that can impair sperm quality.

OMEGA 3’S

Essential fatty acids are necessary to the production of healthy sperm. They improve sperm membranes and protect sperm from oxidative stress. Omega-3s stimulate blood flow to sexual organs and improve sexual function. Inadequate intake of these fatty acids has been linked to poor sperm quality, abnormal sperm, poor motility, and low sperm count, largely because of their role in membrane structure.

Previous research has shown that men with poor sperm counts saw improvement after taking fish oil supplements high in omega-3 fats. A 2012 study by the journal Human Reproduction, found that high intake of omega-3 fats was linked to more normal sperm size and shape, while high intake of saturated fat (the bad fats, aka Trans Fats) was related to lower sperm concentration

Acetyl-L-Carnitine is concentrated in the epididymis, it acts as an antioxidant, protecting spermatozoa against damage caused by reactive oxygen species. This is where sperm mature and acquire their motility. Studies have shown that Acetyl-L-carnitine supplementation for three to four months can significantly improver sperm function and fertility.

Mendiola J, Torres-Cantero AM, Vioque J, et al. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil Steril. 2010 Mar 1;93(4):1128-33.

Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.

Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009 Jul;74(1):73-6.

Safarinejad MR, Hosseini SY, Dadkhah F, Asgari MA. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clin Nutr. 2010 Feb;29(1):100-5.

Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med. 1997;18 Suppl:S213-9.

Schmid TE, Eskenazi B, Marchetti F, et al. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril. 2012 Aug 23.

ANTI-AGING BAR

Barology Anti-Aging Bars, powered by NIAGEN®, takes Anti-Aging to the next level. Our revolutionary LIVE YOUNGER™ Bars, are formulated with NIAGEN® to provide the Next-generation form of Vitamin B3 called NR (Nicotinamide Riboside). This form of B3 optimizes the activation of anti-aging mechanisms in the body, enhances energy metabolism and protects against oxidative stress. NR is a powerful vitamin to assist in production of NAD+ (nicotinamide adenine dinucleotide), which is a molecule found in every cell in the body that is used to power metabolism, construct new cellular components, resist free radical and DNA damage and send signals within the cells. NAD+ enables the mitochondria – the powerhouses of the cell – to convert food into the energy our bodies need to sustain all functions. NAD+ is also required to “turn off” genes implicated in accelerating the aging process. The issue is, as we age (after puberty) our NAD+ level rapidly decline. Barology Anti-Aging Bars provide the optimal level of NAD+ producing NR via NIAGEN. The NIAGEN, combined with real food in a delicious bar, are part of the LIVE YOUNGER lifestyle.

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The Vitamin B3 Family – Related but Different

Vitamin B3‘s are in a class called water-soluble vitamins and are known for their role in activating cellular energy production. Which is why they are sometimes referred to as the “ener-b’s.”4

Within the vitamin B3 family, there are three individual members: niacin (also known as nicotinic acid or NA), nicotinamide (sometimes referred to as niacinamide or NAM) and nicotinamide riboside (NR). None of the forms are related to the nicotine found in tobacco, although their names are similar.

While, it is true that each of these very similar sounding compounds all belong to the vitamin B3 family, it is important for you to think of this group of individuals more like extended family than immediate family. What do we mean by that, exactly? While they share some similarities, like extended families share some genetic commonalities and possibly the same last name, each molecule’s structural uniqueness causes them to be used differently by the body. These differences contribute to the varying effectiveness of each in the various endpoints for which they have been studied.

Pre-clinical studies7 have proven that there are significant differences in each of the B3 molecule’s ability to effectively support our body’s longevity promoting mechanisms, as well as cellular energy production.


What We Need to Know About Each of the Vitamin B3s

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NA (nicotinic acid/niacin)

  • Discovered in the late 1930’s
  • Identified as a treatment for pellagra, which is the late stage of severe niacin deficiency. Pellagra was common in the southern US during the early 1900s where income was low and corn products were a major dietary staple.5
  • Found in foods including yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains
  • The most commonly recognized Bdue to its use as a treatment for elevated cholesterol for decades
  • Known to cause an uncomfortable side effect called ‘flushing’ when taken as a supplement6
  • Tryptophan can be converted to niacin within the body, although the efficiency of conversion is low in humans6

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Nam (nicotinamide)

  • Discovered in the late 1930’s around the same time as NA
  • Derivative (metabolite) of NA6 and NR
  • Sometimes referred to as niacinamide
  • Became popular due to the fact that it is not known to cause flushing
  • The form of niacin typically used in nutritional supplements and in food fortification6
  • “Turns off” longevity promoting proteins within the cells called sirtuins when consumed in higher doses

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NR (nicotinamide riboside)

  • Discovered in the 1940’s
  • Identified as a natural product found in trace amounts in milk in 2004 by Dr. Charles Brenner
  • At the same time, Brenner also discovered the gene (NRK1) which enables NR to boost NAD+ levels in humans1
  • “Turns on” or activates longevity promoting proteins (Sirt2)
  • Not known to cause flushing

References

  • Bieganowski, P. & Brenner, C. (2004). Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117, 495-502.
  • Trammel, S. A., Yu, L., Migaud, M.E., Brenner, C.(2016). Nicotinamide riboside is a major NAD+ precursor vitamin in cow milk. Journal of Nutrition, 146(5), 957–63.
  • Chi Y & Suave AA (2013) Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Current Opinion in Clin. Nutr. and Metab. Care 16, 657-661.
  • Wylde, B. (2016, October 12). Published studies reveal how a superior form of vitamin B3 called NR may play an important role in helping us enjoy longer, healthier lives – Diet & Nutrition Info and Tips. Retrieved November 02, 2016, from http://www.empowher.com/community/share/published-studies-reveal-how-superior-form-vitamin-b3-called-nr-may-play-im
  • Linus Pauling Institute – Micronutrient Information Center. Niacin. Retrieved October, 2016.http://lpi.oregonstate.edu/mic/vitamins
  • Higdon, J., PhD., V. J. Drake PhD, B. Delage PhD. Linus Pauling Institute – Micronutrient Information Center. Niacin, Retrieved August, 2016, from http://lpi.oregonstate.edu/mic/vitamins/niacin
  • Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Abel, E.D., Migaud, M.E., Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948. doi:10.1038/ncomms12948
  • Nature Education. (2014). Cell Energy and Cell Functions. Retrieved October 17, 2016, from http://www.nature.com/scitable/topicpage/cell-energy-and-cell-functions-14024533
  • Belenky, P., Racette, K.L., Bogan, K.L., McClure, J.M., Smith, J.S. & Brenner, C. (2007). Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+. Cell 129, 473-484

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Decline in NAD+ Level with Age

Graph based on data from Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue. PLoS ONE, 7(7). doi:10.1371/journal.pone.0042357

NAD+ is Essential for Life
NAD+ stands for nicotinamide adenine dinucleotide.

NAD+ is a molecule found in every cell in the body that is used to power metabolism, construct new cellular components1, resist free radical and DNA damage and send signals within the cells.2,3 It enables the mitochondria – the ‘powerhouses of the cell’ to convert the food we eat into the energy our body needs to sustain all its functions. It is also required to “turn off” genes implicated in accelerating aging processes.4,5

Healthy mitochondrial function, is an important component of healthy human aging. Our body naturally has the ability to make NAD+ from components in the food we eat. Research in laboratory animals and people shows that as we age, levels of NAD+ declines substantially. This decline leaves us at greater risk for neuro and muscular degeneration6, declines in our cardiometabolic health7 and our capacity for repair and resiliency.

Research suggests NAD+ is key to increasing the amount of time we spend in good health.4-7

What Environmental and Lifestyle Factors Can Impact NAD+ Levels?
Research in animal models suggests that there are a number of lifestyle and environmental factors that impact natural NAD+ levels:

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Scientists at prestigious research institutions have been investigating NAD+ boosting strategies as a therapy for degenerative conditions related to aging. Research indicates that NAD+ plays a unique role in muscle and tissue protection, as well as increasing lifespan.4,8

References

  • Nature Education. (2014). Cell Energy and Cell Functions. Retrieved October 17, 2016, from http://www.nature.com/scitable/topicpage/cell-energy-and-cell-functions-14024533
  • Canto C, Auwerx J. NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:291–298. doi: 10.1101/sqb.2012.76.010439.
  • Ziegler M. New functions of a long-known molecule. Emerging roles of NAD in cellular signaling. Eur. J. Biochem. 2000;267:1550–1564.
  • Belenky, P., Racette, F. G., Bogan, K. L., Mcclure, J. M., Smith, J. S., & Brenner, C. (2007). Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell, 129(3), 473-484. doi:10.1016/j.cell.2007.03.024
  • Imai, S., & Guarente, L. (2014). NAD and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471. doi:10.1016/j.tcb.2014.04.002
  • Frederick, D., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I., . . . Baur, J. (2016, August). Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metabolism, 24(2), 269-282. doi:10.1016/j.cmet.2016.07.005
  • Gomes, A., Price, N., Ling, A., Moslehi, J., Montgomery, M. K., Rajman, L., . . . Sinclair, D. (2013). Declining NAD Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell, 155(7), 1624-1638. doi:10.1016/j.cell.2013.11.037
  • Prolla, T., & Denu, J. (2014). NAD Deficiency in Age-Related Mitochondrial Dysfunction. Cell Metabolism, 19(2), 178-180. doi:10.1016/j.cmet.2014.01.005
  • Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013). NAD metabolism: A therapeutic target for age-related metabolic disease. Critical Reviews in Biochemistry and Molecular Biology, 48(4), 397-408. doi:10.3109/10409238.2013.789479

For more information on the latest studies on NR & NAD+ go to aboutnr.com